RELATION BETWEEN 25-HYDROXYVITAMIN-D3, APOLIPOPROTEIN-A-I, AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL

被引：99

作者：

AUWERX, J

BOUILLON, R

KESTELOOT, H

机构：

[1] CATHOLIC UNIV LEUVEN, DEPT EPIDEMIOL, CAPUCIJNENVOER 33, B-3000 LOUVAIN, BELGIUM

[2] CATHOLIC UNIV LEUVEN, DEPT DEV BIOL, EXPTL MED & ENDOCRINOL LAB, B-3000 LOUVAIN, BELGIUM

来源：

ARTERIOSCLEROSIS AND THROMBOSIS | 1992年 / 12卷 / 06期

关键词：

APOLIPOPROTEIN-A-I; APOLIPOPROTEIN-B; ATHEROSCLEROSIS; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; 25-HYDROXYVITAMIN-D3;

D O I：

10.1161/01.ATV.12.6.671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a survey of cardiovascular risk factors in 185 men and 173 women of a Belgian population group, an independent and highly significant positive correlation was found between the serum concentrations of 25-hydroxyvitamin D3 and apolipoprotein A-I (p<0.001 in both sexes). 25-Hydroxyvitamin D3 also showed a positive correlation with high density lipoprotein cholesterol levels (p<0.05 in men and p<0.005 in women). This relation was independent of a possible effect of 25-hydroxyvitamin D3 on serum calcium. Taking the biological variation of 25-hydroxyvitamin D3 levels (+/-2 SD=25 ng/ml) into account, these findings could explain variations in the levels of apolipoprotein A-1 of 15 mg/100 ml and of high density lipoprotein cholesterol of 4 mg/100 ml.

引用

页码：671 / 674

页数：4

共 21 条

[1]

ANTONENKO LV, 1990, UKR BIOKHIM ZH+, V62, P54

[2]

BOUILLON R, 1984, CLIN CHEM, V30, P1731

[3] EFFECT OF DIFFERENT DOSES OF VITAMIN-D ON SERUM CHOLESTEROL AND TRIGLYCERIDE LEVELS IN HEALTHY MEN [J].