THE AMYLOID BETA-PROTEIN PRECURSOR OR PROTEINASE NEXIN-II FROM MOUSE IS CLOSER RELATED TO ITS HUMAN HOMOLOG THAN PREVIOUSLY REPORTED

被引：31

作者：

DESTROOPER, B ^{[1
]}

VANLEUVEN, F ^{[1
]}

VANDENBERGHE, H ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,CAMPUS GASTHUISBERG,HEREST 49,B-3000 LOUVAIN,BELGIUM

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1129卷 / 01期

关键词：

ALZHEIMER; AMYLOID PRECURSOR PROTEIN; PROTEINASE NEXIN-II; (MOUSE);

D O I：

10.1016/0167-4781(91)90231-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNA sequence for amyloid precursor protein and the two alternatively spliced forms were determined. Seven nucleotide differences resulting in six amino acid differences compared to the previously published mouse sequence were found. Moreover, the 3' non-coding end was completely different. Part of these findings were confirmed in three different mouse strains. The resulting mouse cDNA resembles the human APP more closely than originally reported.

引用

页码：141 / 143

页数：3

共 11 条

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