RANDOMIZED, CONTROLLED TRIAL OF ANTIBIOTIC-THERAPY FOR ESCHERICHIA-COLI O157-H7 ENTERITIS

被引：124

作者：

PROULX, F ^{[1
]}

TURGEON, JP ^{[1
]}

DELAGE, G ^{[1
]}

LAFLEUR, L ^{[1
]}

CHICOINE, L ^{[1
]}

机构：

[1] UNIV MONTREAL, HOP ST JUSTINE, DEPT MICROBIOL & IMMUNOL, MONTREAL H3T 1C5, QUEBEC, CANADA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 121卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(05)81209-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We undertook a prospective, controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven Escherichia coli O157:H7 enteritis on the duration of symptoms, on fecal excretion of pathogen, and on the risk of progression to hemolytic-uremic syndrome. There was no statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion, or the incidence of HUS (2/22 vs 4/25; p = 0.67). Our results suggest that a multicentric trial using rapid diagnostic methods to permit early randomization should be carried out.

引用

页码：299 / 303

页数：5

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