INFLUENCE OF PALMITATE AND BENZOATE ON THE UNIDIRECTIONAL CHIRAL INVERSION OF IBUPROFEN IN ISOLATED RAT HEPATOCYTES

被引：15

作者：

MULLER, S ^{[1
]}

MAYER, JM ^{[1
]}

ETTER, JC ^{[1
]}

TESTA, B ^{[1
]}

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,BEP,CH-1015 LAUSANNE,SWITZERLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 07期

关键词：

D O I：

10.1016/0006-2952(92)90551-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of benzoic acid, a typical substrate of medium-chain acyl-CoA synthetase, and of palmitic acid, a substrate of long-chain acyl-CoA synthetase, on the metabolic chiral inversion of ibuprofen was investigated in freshly isolated hepatocytes. It was shown that the conjugation of benzoid to hippuric acid does not influence the chiral inversion of ibuprofen. In contrast, palmitic acid inhibited markedly the R-to-S inversion of ibuprofen. It was concluded that this inhibition is due to competition between (R)-ibuprofen and palmitic acid for long-chain acyl-CoA synthetases.

引用

页码：1468 / 1470

页数：3

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