A CONVENIENT STRATEGY FOR REPLACEMENT OF THE ANOMERIC HYDROXYL GROUP BY DIFLUOROMETHYL FUNCTIONALITY IN CARBOHYDRATE-DERIVATIVES

被引：69

作者：

HOULTON, JS

MOTHERWELL, WB

ROSS, BC

TOZER, MJ

WILLIAMS, DJ

SLAWIN, AMZ

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] GLAXO GRP RES LTD,WARE SG12 0DJ,HERTS,ENGLAND

[3] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,CHEM CRYSTALLOG LAB,LONDON SW7 2AY,ENGLAND

来源：

TETRAHEDRON | 1993年 / 49卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(01)88029-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of carbohydrate gem-difluoroenol ethers are readily prepared by the reaction of the corresponding lactones with dibromodifluoromethane, tris(dimethylamino)phosphine and zinc. Subsequent catalytic hydrogenation provides difluoromethyl C-glycoside analogues in which the exocyclic oxygen atom has been replaced by a difluoromethylene unit.

引用

页码：8087 / 8106

页数：20

共 17 条

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