MODULATION OF THE RESPIRATORY BURST IN HUMAN NEUTROPHILS BY ISOPROTERENOL AND DIBUTYRYL-CYCLIC-AMP

被引：25

作者：

GIBSONBERRY, KL ^{[1
]}

WHITIN, JC ^{[1
]}

COHEN, HJ ^{[1
]}

机构：

[1] UNIV ROCHESTER, SCH MED & DENT, STRONGS CHILDREN RES CTR, ROCHESTER, NY 14642 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 43卷 / 1-2期

关键词：

POLYMORPHONUCLEAR NEUTROPHIL; NADPH OXIDASE; TERMINATION CONSTANTS; ISOPROTERENOL; DIBUTYRYL CYCLIC AMP;

D O I：

10.1016/0165-5728(93)90075-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of a beta-adrenergic agonist and a cyclic AMP analogue on activation, activity, and termination of FMLP-stimulated superoxide anion production were investigated. Incubation with isoproterenol resulted in a 50% reduction in the maximal rate of superoxide production and a 3-4-fold increase in the rate of termination of superoxide production. Exposure to 1 mM dibutyryl cyclic AMP resulted in a 40% decrease in the maximal rate and a 3-fold increase in the rate of termination of FMLP-induced superoxide production. Neither agent had a significant effect on the lag time prior to superoxide anion generation.

引用

页码：59 / 68

页数：10

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