ESTROGEN-INDUCTION OF DENDRITIC SPINES IN VENTROMEDIAL HYPOTHALAMUS AND HIPPOCAMPUS - EFFECTS OF NEONATAL AROMATASE BLOCKADE AND ADULT GDX

被引：74

作者：

LEWIS, C

MCEWEN, BS

FRANKFURT, M

机构：

[1] Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 87卷 / 01期

关键词：

DENDRITIC SPINE; ESTROGEN; GONADECTOMY; AROMATASE; VMN; HIPPOCAMPUS;

D O I：

10.1016/0165-3806(95)00052-F

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Treatment of male rats at birth with an aromatase inhibitor (Letrazole), followed by adult gonadectomy GDX, led to an increase in dendritic spine density on ventromedial hypothalamic neurons (VMN) when treated with estrogen as compared to a decrease when vehicle animals were given estrogen. In contrast, estrogen-treatment increased dendritic spine density on CA1 pyramidal neurons regardless of neonatal treatment. In addition, in CA1 there was a significant difference between the two estrogen groups. These results suggest that estrogen induction of dendritic spines in the VMN and CA1 is dependent on organizational effects of gonadal steroids.

引用

页码：91 / 95

页数：5

共 29 条

[1]

ARAI Y, 1986, PSYCHONEUROENDOCRINO, V3, P31

[2] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].

ARNOLD, AP ;

GORSKI, RA .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :413-442

[3] ORGANIZATIONAL AND ACTIVATIONAL EFFECTS OF SEX STEROIDS ON BRAIN AND BEHAVIOR - A REANALYSIS [J].

ARNOLD, AP ;

BREEDLOVE, SM .

HORMONES AND BEHAVIOR, 1985, 19 (04) :469-498

[4]

BREEDLOVE SM, 1992, J NEUROSCI, V12, P4133

[5] ULTRASTRUCTURAL-CHANGES IN THE HYPOTHALAMIC VENTROMEDIAL NUCLEUS OF OVARIECTOMIZED RATS AFTER ESTROGEN-TREATMENT [J].

CARRER, HF ;

AOKI, A .

BRAIN RESEARCH, 1982, 240 (02) :221-233

[6] DISTRIBUTION OF ESTROGEN RECEPTOR-IMMUNOREACTIVE CELLS IN THE FOREBRAIN OF THE FEMALE GUINEA-PIG [J].

DONCARLOS, LL ;

MONROY, E ;

MORRELL, JI .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 305 (04) :591-612

[7] ESTROGEN INCREASES AXODENDRITIC SYNAPSES IN THE VMN OF RATS AFTER OVARIECTOMY [J].

FRANKFURT, M ;

MCEWEN, BS .

NEUROREPORT, 1991, 2 (07) :380-382

[8] 5,7-DIHYDROXYTRYPTAMINE AND GONADAL-STEROID MANIPULATION ALTER SPINE DENSITY IN VENTROMEDIAL HYPOTHALAMIC NEURONS [J].

FRANKFURT, M ;

MCEWEN, BS .

NEUROENDOCRINOLOGY, 1991, 54 (06) :653-657

[9] GONADAL-STEROIDS MODIFY DENDRITIC SPINE DENSITY IN VENTROMEDIAL HYPOTHALAMIC NEURONS - A GOLGI-STUDY IN THE ADULT-RAT [J].

FRANKFURT, M ;

GOULD, E ;

WOOLLEY, CS ;

MCEWEN, BS .

NEUROENDOCRINOLOGY, 1990, 51 (05) :530-535

[10]

GORSKI RA, 1983, NEUROENDOCRINE PERSP, V2, P1

← 1 2 3 →