ADDITIVE EFFECT OF CLARITHROMYCIN COMBINED WITH 14-HYDROXY CLARITHROMYCIN, ERYTHROMYCIN, AMOXICILLIN, METRONIDAZOLE OR OMEPRAZOLE AGAINST HELICOBACTER-PYLORI

被引：57

作者：

CEDERBRANT, G

KAHLMETER, G

SCHALEN, C

KAMME, C

机构：

[1] UNIV LUND HOSP,DEPT CLIN MICROBIOL,S-22362 LUND,SWEDEN

[2] CENT HOSP VAXJO,DEPT CLIN MICROBIOL,VAXJO,SWEDEN

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1994年 / 34卷 / 06期

关键词：

D O I：

10.1093/jac/34.6.1025

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vitro activities of clarithromycin, 14-OH clarithromycin, erythromycin, amoxycillin, metronidazole and omeprazole against Helicobacter pylori were determined at pH 7.2 and 5.5. At pH 5.5 the activities of clarithromycin and erythromycin decreased approximately 16 times while 14-OH clarithromycin was less influenced. Chequerboard titration indicated that the combined activity of clarithromycin and the other compounds was additive.

引用

页码：1025 / 1029

页数：5

共 11 条

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