STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF THE ROD OUTER SEGMENT MEMBRANE GUANYLATE-CYCLASE

被引：127

作者：

GORACZNIAK, RM

DUDA, T

SITARAMAYYA, A

SHARMA, RK

机构：

[1] PENN COLL OPTOMETRY,REGULATORY & MOLEC BIOL UNIT,PHILADELPHIA,PA 19141

[2] OAKLAND UNIV,EYE RES INST,ROCHESTER,MI 48309

来源：

BIOCHEMICAL JOURNAL | 1994年 / 302卷

关键词：

D O I：

10.1042/bj3020455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the vertebrate photoreceptor cell, rod outer segment (ROS) is the site of visual signal-transduction process, and a pivotal molecule that regulates this process is cyclic GMP. Cyclic GMP controls the cationic conductance in the ROS, and light causes a decrease in the conductance by activating hydrolysis of the cyclic nucleotide. The identity of the guanylate cyclase (ROS-GC) that synthesizes this pool of cyclic GMP is unknown. We now report the cloning, expression and functional characterization of a DNA from bovine retina that encodes ROS-GC.

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页码：455 / 461

页数：7

相关论文

共 25 条

[1] DIFFERENTIAL LAMINAR EXPRESSION OF PARTICULATE AND SOLUBLE GUANYLATE-CYCLASE GENES IN RAT RETINA [J].

AHMAD, I ;

BARNSTABLE, CJ .

EXPERIMENTAL EYE RESEARCH, 1993, 56 (01) :51-62

[2] A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR [J].

CHINKERS, M ;

GARBERS, DL ;

CHANG, MS ;

LOWE, DG ;

CHIN, HM ;

GOEDDEL, DV ;

SCHULZ, S .

NATURE, 1989, 338 (6210) :78-83

[3]

DESAUVAGE FJ, 1991, J BIOL CHEM, V266, P17912

[4] CORE SEQUENCE OF ATP REGULATORY MODULE IN RECEPTOR GUANYLATE CYCLASES [J].

DUDA, T ;

GORACZNIAK, RM ;

SHARMA, RK .

FEBS LETTERS, 1993, 315 (02) :143-148

[5] THE GLYCINE RESIDUE OF ATP REGULATORY MODULE IN RECEPTOR GUANYLATE CYCLASES THAT IS ESSENTIAL IN NATRIURETIC FACTOR SIGNALING [J].

DUDA, T ;

GORACZNIAK, RM ;

SHARMA, RK .

FEBS LETTERS, 1993, 335 (03) :309-314

[6] CLONING AND EXPRESSION OF AN ATP-REGULATED HUMAN RETINA C-TYPE NATRIURETIC FACTOR RECEPTOR GUANYLATE-CYCLASE [J].

DUDA, T ;

GORACZNIAK, RM ;

SITARAMAYYA, A ;

SHARMA, RK .

BIOCHEMISTRY, 1993, 32 (06) :1391-1395

[7] SITE-DIRECTED MUTATIONAL ANALYSIS OF A MEMBRANE GUANYLATE-CYCLASE CDNA REVEALS THE ATRIAL-NATRIURETIC-FACTOR SIGNALING SITE [J].

DUDA, T ;

GORACZNIAK, RM ;

SHARMA, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7882-7886

[8]

DUDA TM, 1992, INVEST OPHTH VIS SCI, V33, P1400

[9]

FEINBERG AP, 1984, ANAL BIOCHEM, V132, P6

[10] GUANYLATE-CYCLASE FROM BOVINE ROD OUTER SEGMENTS - SOLUBILIZATION, PARTIAL-PURIFICATION, AND REGULATION BY INORGANIC PYROPHOSPHATE [J].

HAKKI, S ;

SITARAMAYYA, A .

BIOCHEMISTRY, 1990, 29 (04) :1088-1094