STUDY OF NALOXONE IN NORMAL AWAKE MAN - EFFECTS ON SPINAL REFLEXES

被引:40
作者
BOUREAU, F
WILLER, JC
DAUTHIER, C
机构
[1] Laboratoire de Physiologie, Faculté de Médecine Saint-Antoine, 75571 Paris Cedex 12, 27, rue Chaligny
关键词
endorphin; naloxone; normal man; spinal reflexes;
D O I
10.1016/0028-3908(78)90149-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of this work was to study the effects of naloxone (0.8 mg, 3 cm3i.v.) compared with a placebo (9% NaCl serum, 3 cm3i.v.) on spinal reflexes: monosynaptic (H reflex), polysynaptic tactile (PSR, RII) and nociceptive (PSR, RIII) in awake normal human subjects. The H reflex was significantly facilitated (+16%) whereas no significant variation was noted on PSR, RII and PSR, RIII responses. The excitatory action of naloxone appeared by the 2nd-3rd min following the injection, reached a maximum towards the 7-10th min, and decreased slightly during the end of the session. No significant variation in the above parameters was ever observed with the placebo. The nature of the excitatory effect of naloxone on monosynaptic reflexes and the functional implications of these results are discussed. © 1978.
引用
收藏
页码:565 / 568
页数:4
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