ANALGESIC EFFICACY AND CSF PHARMACOKINETICS OF INTRATHECAL MORPHINE-6-GLUCURONIDE - COMPARISON WITH MORPHINE

被引:125
作者
HANNA, MH
PEAT, SJ
WOODHAM, M
KNIBB, A
FUNG, C
机构
[1] Pain Relief Research Unit, Kings College School of Medicine, London SE5 9PJ, Bessemer Road
关键词
Analgesics: intrathecal morphine; morphine-6-glucuronide; Pharmacokinetics: cerebrospinal fluid;
D O I
10.1093/bja/64.5.547
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Summary: The analgesic efficacy and CSF pharmacokinetics of intrathecal morphine sulphate and morphine-6-glucuronide (M6G) were compared in a single-blind crossover study. Lumbar intrathecal catheters were sited in three patients with chronic cancer pain, and morphine sulphate 500 μg or M6G 500 μg given via the catheter on separate days. CSF was sampled for 24 h following drug administration and analysed for morphine and M6G by high pressure liquid chromatography. The mean (SD) requirement for patient controlled analgesia with pethidine was 393.3 (227.4) mg/24 h during the morphine limb of the trial and 226.7 (113.6) mg/24 h during the M6G limb. M6G was not detected in CSF following administration of morphine. Fitting of CSF concentrations to triexponential curves revealed mean (SD) alpha, beta and gamma half-lives of 13.2 (7.4), 54.9 (31.5) and 222.5 (100) min for morphine and 11.2 (2.4), 67.3 (49.9) and 619.3 (629.7) min for M6G. © 1990 Copyright: 1990 British Journal of Anaesthesia.
引用
收藏
页码:547 / 550
页数:4
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