BIOANALYSIS OF SURAMIN IN HUMAN PLASMA BY ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：16

作者：

TJADEN, UR ^{[1
]}

REEUWIJK, HJEM ^{[1
]}

VANDERGREEF, J ^{[1
]}

PATTYN, G ^{[1
]}

DEBRUIJN, EA ^{[1
]}

VANOOSTEROM, AT ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP,CANC RES & CLIN ONCOL LAB,B-2610 WILRIJK,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 525卷 / 01期

关键词：

D O I：

10.1016/S0378-4347(00)83387-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic method is described that can be used for the determination of suramin in plasma samples from cancer patients treated with this drug. The chromatographic system is based on the use of tetrabutylammonium bromide as an ion-pairing agent, while ultraviolet detection is applied. The sample pretreatment is a simple deproteination step by an organic solvent. The same counter-ion as used in the phase system is added in order to increase the recovery of the almost complete protein-bound suramin. The minimum detectable concentration in plasma is ca. 0.1 μg/ml, thus allowing the monitoring of patients treated with this drug. One example of a plasma concentration-time course after administration of suramin is given. © 1990.

引用

页码：141 / 149

页数：9

共 19 条

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