DEOXYOLIGONUCLEOTIDE ANALOGS BASED ON FORMACETAL LINKAGES

被引：90

作者：

MATTEUCCI, M

机构：

[1] Gilead Sciences, Inc., Foster City, CA 94404

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)97368-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes the synthesis of a trimer of thymidine bearing formacetal linkages, its incorporation into a longer deoxyoligonucleotide and characterization of the hybridization properties with a complementary RNA sequence. © 1990.

引用

页码：2385 / 2388

页数：4

共 19 条

[1] INHIBITION OF RABBIT GLOBIN MESSENGER-RNA TRANSLATION BY SEQUENCE-SPECIFIC OLIGODEOXYRIBONUCLEOTIDES [J].

BLAKE, KR ;

MURAKAMI, A ;

MILLER, PS .

BIOCHEMISTRY, 1985, 24 (22) :6132-6138

[2] SYNTHESIS AND CHARACTERIZATION OF A CARBAMATE-LINKED OLIGONUCLEOSIDE [J].

COULL, JM ;

CARLSON, DV ;

WEITH, HL .

TETRAHEDRON LETTERS, 1987, 28 (07) :745-748

[3] PHOSPHORAMIDATE ANALOGS OF DNA - SYNTHESIS AND THERMAL-STABILITY OF HETERODUPLEXES [J].

FROEHLER, B ;

NG, P ;

MATTEUCCI, M .

NUCLEIC ACIDS RESEARCH, 1988, 16 (11) :4831-4839

[4] DEOXYNUCLEOSIDE H-PHOSPHONATE DIESTER INTERMEDIATES IN THE SYNTHESIS OF INTERNUCLEOTIDE PHOSPHATE ANALOGS [J].

FROEHLER, BC .

TETRAHEDRON LETTERS, 1986, 27 (46) :5575-5578

[5] SYNTHESIS OF DNA VIA DEOXYNUCLEOSIDE H-PHOSPHONATE INTERMEDIATES [J].

FROEHLER, BC ;

NG, PG ;

MATTEUCCI, MD .

NUCLEIC ACIDS RESEARCH, 1986, 14 (13) :5399-5407

[6] OLIGONUCLEOTIDE N-ALKYLPHOSPHORAMIDATES - SYNTHESIS AND BINDING TO POLYNUCLEOTIDES [J].

JAGER, A ;

LEVY, MJ ;

HECHT, SM .

BIOCHEMISTRY, 1988, 27 (19) :7237-7246

[7]

LETSINGER RL, 1986, NUCLEIC ACIDS RES, V14, P5399

[8] NUCLEOTIDE CHEMISTRY .4. SYNTHESIS OF DEOXYOLIGONUCLEOTIDES ON A POLYMER SUPPORT [J].

MATTEUCCI, MD ;

CARUTHERS, MH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (11) :3185-3191

[9] SYNTHESIS AND TEMPLATE PROPERTIES OF AN ETHYL PHOSPHOTRIESTER MODIFIED DECADEOXYRIBONUCLEOTIDE [J].

MILLER, PS ;

CHANDRASEGARAN, S ;

DOW, DL ;

PULFORD, SM ;

KAN, LS .

BIOCHEMISTRY, 1982, 21 (22) :5468-5474

[10] CONFORMATION AND INTERACTION OF DINUCLEOSIDE MONOPHOSPHATES AND DIPHOSPHATES .5. SYNTHESES AND PROPERTIES OF ADENINE AND THYMINE NUCLEOSIDE ALKYL PHOSPHOTRIESTERS, NEUTRAL ANALOGS OF DINUCLEOSIDE MONOPHOSPHATES [J].

MILLER, PS ;

FANG, KN ;

KONDO, NS ;

TSO, POP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (24) :6657-&

← 1 2 →