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SOMATOSTATIN INHIBITION OF VIP-STIMULATED AND ISOPROTERENOL-STIMULATED CYCLIC-AMP ACCUMULATION IN DISSOCIATED CELLS FROM RAT CEREBRAL-CORTEX

被引：8
作者：
COLAS, B
RUIZ, MPL
PRIETO, JC
ARILLA, E
机构：
[1] Departmento de Bioquimica y Biologia Molecular, Facultad de Medicina Universidad de Alcala de Henares, Madrid
来源：
NEUROPEPTIDES | 1990年 / 15卷 / 04期
关键词：
D O I：
10.1016/0143-4179(90)90018-T
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Freshly dissociated cerebral cortex cells from adult rats have been used in the present study to determine if dual regulation of cyclic AMP levels by inhibitory and stimulatory agents can be expressed in the mature brain. Somatostatin, an inhibitory agent, barely affected the basal cyclic AMP metabolism while vasoactive intestinal peptide (VIP) and isoproterenol, two stimulatory agents enhanced cyclic AMP production. However, this increase was depressed by somatostatin, which decreased the efficiency, but not the potency, of the effects of the two stimulatory agents on cyclic AMP accumulation. © 1990.
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收藏
页码：235 / 239
页数：5
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