NEW CHEMOENZYMATIC SYNTHESIS OF (R)-4-(PHENYLSULFONYL)-2-METHYL-1-BUTANOL AND (S)-4(PHENYLSULFONYL)-2-METHYL-1-BUTANOL - A CHIRAL C5 ISOPRENOID SYNTHON

被引：24

作者：

FERRABOSCHI, P

GRISENTI, P

MANZOCCHI, A

SANTANIELLO, E

机构：

[1] UNIV MILAN,FAC MED,DIPARTIMENTO CHIM & BIOCHIM MED,VIA SALDINI 50,I-20133 MILAN,ITALY

[2] UNIV MILAN,FAC FARM,IST ENDOCRINOL,I-20133 MILAN,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 25期

关键词：

D O I：

10.1021/jo00312a032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral C5isoprenoid synthon of general formula 1 is a useful intermediate for the synthesis of various natural products and has been prepared by several chemoenzymatic approaches.1 We had already prepared one of the possible synthetic equivalents of 1, namely, (S)-(-)-l-(ethoxymethoxy)-2-methyl-4-(phenylthio)butane (2a), and used it for a new synthesis of (25S)-26-hydroxycholesterol.2. © 1990, American Chemical Society. All rights reserved.

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页码：6214 / 6216

页数：3

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