BIOLOGICAL ASPECTS OF CYTOSINE METHYLATION IN EUKARYOTIC CELLS

被引：90

作者：

HERGERSBERG, M

机构：

[1] Institut für Molekularbiologie II der Universität Zürich, Zürich, CH-8093, Hönggerberg

来源：

EXPERIENTIA | 1991年 / 47卷 / 11-12期

关键词：

D O I：

10.1007/BF01918381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The existence in eukaryotes of a fifth base, 5-methylcytosine, and of tissue-specific methylation patterns have been known for many years, but except for a general association with inactive genes and chromatin the exact function of this DNA modification has remained elusive. The different hypotheses regarding the role of DNA methylation in regulation of gene expression, chromatin structure, development, and diseases, including cancer are summarized, and the experimental evidence for them is discussed. Structural and functional properties of the eukaryotic DNA cytosine methyltransferase are also reviewed.

引用

页码：1171 / 1185

页数：15

共 219 条

[1]

ADAMS RLP, 1988, GENE, V74, P125

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