ATRIAL-NATRIURETIC-PEPTIDE SUPPRESSES OSMOSTIMULATED VASOPRESSIN RELEASE IN YOUNG AND ELDERLY HUMANS

被引:34
作者
CLARK, BA
ELAHI, D
FISH, L
MCALOONDYKE, M
DAVIS, K
MINAKER, KL
EPSTEIN, FH
机构
[1] HARVARD UNIV, BETH ISRAEL HOSP,SCH MED,CHARLES A DANA RES INST, DEPT MED,DIV GERONTOL, BOSTON, MA 02215 USA
[2] BROCKTON W ROXBURY DEPT VET AFFAIRS MED CTR, CTR GERIATR RES EDUC CLIN, BOSTON, MA 02132 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 02期
关键词
AGING; OSMOLALITY; VOLUME EXPANSION; POSTERIOR PITUITARY;
D O I
10.1152/ajpendo.1991.261.2.E252
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Atrial natriuretic peptide (ANP) may suppress vasopressin release, but the dynamics of this interaction as well as the influence of age have not been defined. We studied six or seven young (19-40 yr old) and seven elderly volunteers (65-83 yr old) under two circumstances: 1) after infusion of 5% saline (0.04 ml.kg-1.min-1) for 2 h and 2) after the same infusion given with simultaneous synthetic human ANP (0.05-mu-g.kg-1.min-1). Hypertonic saline alone produced a progressive rise in plasma vasopressin with increasing serum sodium. During hypertonic saline alone, vasopressin levels began to rise at an increment in serum sodium of 1.67 +/- 0.35 mM in the young and 1.43 +/- 0.32 mM in the elderly and rose linearly with increasing serum sodium. When ANP was infused with hypertonic saline (with peak ANP levels of approximately 1,000 pM), vasopressin levels began to rise at an increment in serum sodium of 4.43 +/- 0.67 mM in the young and 4.57 +/- 0.43 mM in the elderly (P < 0.01 vs. saline alone). Furthermore, the vasopressin response for any given serum sodium was significantly reduced in both young and elderly subjects, resulting in a rightward displacement of the curve relating vasopressin response to sodium concentration (P < 0.001). In conclusion, ANP not only suppresses vasopressin but raises the threshold for release of vasopressin in response to osmotic stimulation in both young and elderly individuals. High circulating ANP levels may be responsible in part for the suppression of vasopressin levels and water diuresis seen during states of volume expansion.
引用
收藏
页码:E252 / E256
页数:5
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