CHANGES IN THYROTROPIN RECEPTOR ANTIBODY AFTER SUBTOTAL THYROIDECTOMY IN GRAVES-DISEASE - COMPARISON WITH THE DEGREE OF LYMPHOCYTIC INFILTRATION IN THE THYROID

被引：9

作者：

CHO, BY

OH, SK

SHONG, YK

KIM, SE

YOO, HY

LEE, HK

KOH, CS

MIN, HK

机构：

[1] Department of General Surgery, Seoul National University College of Medicine, Seoul

[2] Department of Internal Medicine, Seoul, 138-040, Asan Medical Center

来源：

AUTOIMMUNITY | 1990年 / 8卷 / 02期

关键词：

THYROTROPIN RECEPTOR ANTIBODY; GRAVES DISEASE; SUBTOTAL THYROIDECTOMY; LYMPHOCYTIC INFILTRATION;

D O I：

10.3109/08916939008995732

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44% out of 50 patients. thyrotropin binding inhibitor immunoglobulin (TBII) levels gradually decreased and disappeared completely within 12 months after surgery (TBII disappearing group). Twenty-eight (56% patients showed persistent TBII activity and their levels were not changed until 12 months after surgery (TBII persistent group). The changes of thyroid stimulating antibody (TSab) levels were very similar to those of TBII in both groups. The thyroidal lymphocytic infiltration was more prominent in the TBII disappearing group. The degree of the decrease of TBII levels after surgery correlated with the grade of thyroidal lymphocytic infiltration. There was no significant difference of TSH receptor antibody (both TBII and TSab) levels between the thyroid and peripheral venous blood. These data suggest that the persistence or disappearance of TSH receptor antibody after surgery may reflect the difference between patients in whom the thyroid is the major site of TSH receptor antibody and those in whom additional sites of TSH receptor antibody synthesis exist. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：143 / 147

页数：5

共 22 条

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