EFFECT OF 17-BETA-ESTRADIOL ON PAF AND PROSTAGLANDIN LEVELS IN OOPHORECTOMIZED RAT UTERUS

被引：24

作者：

NAKAYAMA, R ^{[1
]}

YASUDA, K ^{[1
]}

OKUMURA, T ^{[1
]}

SAITO, K ^{[1
]}

机构：

[1] KANSAI MED UNIV,DEPT MED CHEM,MORIGUCHI,OSAKA 570,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1085卷 / 02期

关键词：

PAF; PROSTAGLANDIN; ARACHIDONIC ACID; GPC; 1-ALKYL-2-ARACHIDONOYL; ESTRADIOL; (OOPHORECTOMIZED RAT UTERUS);

D O I：

10.1016/0005-2760(91)90099-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of 17-beta-estradiol on the levels of platelet-activating factor (PAF) and prostaglandins and their precursor phospholipid in the uterus of oophorectomized rats were studied. Oophorectomy results in the decrease in the uterine PAF level to one-third of that in natural estrus. This level was recovered by subcutaneous administration of 17-beta-estradiol. The level of uterine phospholipids, which are rich in arachidonic acid, was significantly decreased by estradiol treatment. More arachidonate-PC was depleted than arachidonate-PE. The molecular structure was confirmed by gas chromatography-mass spectrometry. The amount of PGF2-alpha in the oophorectomized uterine tissue was 10-times that of PAF, but like the latter, increased 3-4-times on estradiol treatment. The chemical structures of PAF and PGF2-alpha formed on estradiol treatment were confirmed by mass spectrometry. The present data strongly suggest a correlation between the formations of PAF and PGF2-alpha, and indicate that estradiol may regulate the physiological formations of PAF and PGs in non-pregnant rat uterus.

引用

页码：235 / 240

页数：6

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