COMPARISON OF MEASLES-VIRUS SPECIFIC ANTIBODIES WITH ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY AND NEUTRALIZING FUNCTIONS

被引:16
作者
FORTHAL, DN [1 ]
LANDUCCI, G [1 ]
KATZ, J [1 ]
TILLES, JG [1 ]
机构
[1] UNIV CALIF IRVINE,COLL MED,DEPT PEDIAT,IRVINE,CA 92717
关键词
D O I
10.1093/infdis/168.4.1020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Measles virus-specific antibodies with antibody-dependent cellular cytotoxicity (ADCC) and neutralizing functions were compared in 25 healthy women. ADCC antibody was measured in a 12-h Cr-51 release assay using peripheral blood mononuclear cells as effectors and Raji cells persistently infected with measles as targets. Neutralizing antibody was determined by the plaque neutralization test (PNT). ADCC and PNT titers correlated well (r = .80, P <.001). ADCC titers ranged from <1 0 to >10(6) and averaged 1.3 logs higher than PNT titers. Three sera with PNT titers of <1 20, including 1 with a titer of <8 (<10(0.9)), had ADCC titers of greater-than-or-equal-to 10(2.5). Among subjects born in the United States, ADCC titers, but not PNT titers, correlated inversely with the year of birth, suggesting that ADCC antibody may be more indicative than neutralizing antibody of differences between naturally and vaccine-acquired immunity. These data suggest a possible role for ADCC in protection or recovery from measles.
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收藏
页码:1020 / 1023
页数:4
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