PROMOTER RESURRECTION BY ACTIVATORS - A MINIREVIEW

被引：23

作者：

ADHYA, S

GOTTESMAN, M

GARGES, S

OPPENHEIM, A

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,INST CANC RES,NEW YORK,NY 10032

[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOLEC GENET,IL-91010 JERUSALEM,ISRAEL

来源：

GENE | 1993年 / 132卷 / 01期

关键词：

RNA POLYMERASE; SIGMA FACTORS; ACTIVATORS; CRP; IHF;

D O I：

10.1016/0378-1119(93)90507-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Frequently, in nature, defective promoters can be resurrected by activator proteins in response to cellular demands. The activators bind to nearby DNA sites for action. Various protein-protein and DNA-protein contacts involving activators, RNA polymerase, and different segments of DNA in and around a defective promoter form a DNA-multiprotein complex (cage) which enhances transcription.

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页码：1 / 6

页数：6

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[1] MULTIPARTITE GENETIC-CONTROL ELEMENTS - COMMUNICATION BY DNA LOOP [J].

ADHYA, S .

ANNUAL REVIEW OF GENETICS, 1989, 23 :227-250

[2]

ADHYA S, 1990, J BIOL CHEM, V265, P10797

[3] TOPOLOGICAL UNWINDING OF STRONG AND WEAK PROMOTERS BY RNA-POLYMERASE - A COMPARISON BETWEEN THE LAC WILD-TYPE AND THE UV5 SITES OF ESCHERICHIA-COLI [J].

AMOUYAL, M ;

BUC, H .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 195 (04) :795-808

[4] MUTATIONS THAT ALTER THE ABILITY OF THE ESCHERICHIA-COLI CYCLIC-AMP RECEPTOR PROTEIN TO ACTIVATE TRANSCRIPTION [J].

BELL, A ;

GASTON, K ;

WILLIAMS, R ;

CHAPMAN, K ;

KOLB, A ;

BUC, H ;

MINCHIN, S ;

WILLIAMS, J ;

BUSBY, S .

NUCLEIC ACIDS RESEARCH, 1990, 18 (24) :7243-7250

[5] BINDING OF CRP TO DNA-DEPENDENT RNA-POLYMERASE FROM ESCHERICHIA-COLI - MODULATION BY CAMP OF THE INTERACTIONS WITH FREE AND DNA-BOUND HOLO AND CORE ENZYME [J].

BLAZY, B ;

TAKAHASHI, M ;

BAUDRAS, A .

MOLECULAR BIOLOGY REPORTS, 1980, 6 (01) :39-43

[6] KINETICS OF OPEN COMPLEX-FORMATION BETWEEN ESCHERICHIA-COLI RNA-POLYMERASE AND THE LAC UV5 PROMOTER - EVIDENCE FOR A SEQUENTIAL MECHANISM INVOLVING 3 STEPS [J].

BUC, H ;

MCCLURE, WR .

BIOCHEMISTRY, 1985, 24 (11) :2712-2723

[7] A SINGLE GLUTAMIC-ACID RESIDUE PLAYS A KEY ROLE IN THE TRANSCRIPTIONAL ACTIVATION FUNCTION OF LAMBDA REPRESSOR [J].

BUSHMAN, FD ;

SHANG, C ;

PTASHNE, M .

CELL, 1989, 58 (06) :1163-1171

[8] ROLE OF INTEGRATION HOST FACTOR IN THE REGULATION OF THE GLNHP2 PROMOTER OF ESCHERICHIA-COLI [J].

CLAVERIEMARTIN, F ;

MAGASANIK, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) :1631-1635

[9] CONTROL SITE LOCATION AND TRANSCRIPTIONAL REGULATION IN ESCHERICHIA-COLI [J].

COLLADOVIDES, J ;

MAGASANIK, B ;

GRALLA, JD .

MICROBIOLOGICAL REVIEWS, 1991, 55 (03) :371-394

[10] ESCHERICHIA-COLI CATABOLITE GENE ACTIVATOR PROTEIN MUTANTS DEFECTIVE IN POSITIVE CONTROL OF LAC OPERON TRANSCRIPTION [J].

ESCHENLAUER, AC ;

REZNIKOFF, WS .

JOURNAL OF BACTERIOLOGY, 1991, 173 (16) :5024-5029

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