ACQUISITION OF CONTEXTUAL PAVLOVIAN FEAR CONDITIONING IS BLOCKED BY APPLICATION OF AN NMDA RECEPTOR ANTAGONIST D,L-2-AMINO-5-PHOSPHONOVALERIC ACID TO THE BASOLATERAL AMYGDALA

被引：328

作者：

FANSELOW, MS

KIM, JJ

机构：

[1] Department of Psychology, University of California, Los Angeles, CA 90024-1563

来源：

BEHAVIORAL NEUROSCIENCE | 1994年 / 108卷 / 01期

关键词：

D O I：

10.1037/0735-7044.108.1.210

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats, with chronic cannula placed bilaterally in the amygdala, received infusions of the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV) before contextual Pavlovian fear conditioning. Administration of APV to the basolateral nucleus prevented acquisition of fear. Central nucleus infusions had no effect. It is concluded that an NMDA-mediated process near the basolateral region of the amygdala (e.g., lateral or basolateral nucleus) is essential for the learning of fear.

引用

页码：210 / 212

页数：3

共 18 条

[1] INTRAAMYGDALA INFUSION OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST AP5 BLOCKS ACQUISITION BUT NOT EXPRESSION OF FEAR-POTENTIATED STARTLE TO AN AUDITORY CONDITIONED-STIMULUS [J].