COMPARISON OF THE HEMODYNAMIC AND OXYGEN-TRANSPORT RESPONSES TO MODIFIED FLUID GELATIN AND HETASTARCH IN CRITICALLY ILL PATIENTS - A PROSPECTIVE, RANDOMIZED TRIAL

Objective: To compare the hemodynamic and oxygen transport responses to a rapid (<10-min) infusion of 500 mL of modified fluid gelatin (group A) or hydroxyethyl starch (group B) in patients suffering from acute hypovolemia. Design: Prospective, randomized, noncrossover study. Setting: University hospital, general intensive care unit. Patients: Twenty-eight patients with hypovolemia mechanically ventilated for concurrent acute respiratory failure. Interventions: Patients were mechanically ventilated. Pulmonary and femoral artery catheters were used for hemodynamic monitoring. Measurements and Main Results: Hemodynamic and oxygen transport variables were determined at baseline, 15 mins, and 30 mins after the infusion of each fluid. In both groups pulmonary artery occlusion pressure, stroke volume, and cardiac index significantly increased. In neither group did heart rate decrease. Oxygen delivery increased significantly in group A patients but not in group B patients. This result was due to greater hemodilution in group B patients. Conclusions: There are no significant differences in the hemodynamic responses to hydroxyethyl starch or modified fluid gelatin. The hemodynamic and oxygen transport effects of artificial colloid solutions may not be entirely predictable and should be monitored in critically ill patients.