STOCHASTIC DEVELOPMENT OF STEM CELLS

被引：58

作者：

VOGEL, H

NIEWISCH, H

MATIOLI, G

机构：

[1] Department of Microbiology, University of Southern California, School of Medicine, Los Angeles, CA

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1969年 / 22卷 / 02期

关键词：

D O I：

10.1016/0022-5193(69)90004-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The stochastic model of Till, McCulloch & Siminovitch (1964) for the development of a colony from a stem cell is generalized, and expressions are derived for the moments of any order of the stem cell distribution, especially mean and standard deviation. Furthermore, expressions for the probability for the extinction of a colony are given. The model is applied principally to the development of erythroblastic colonies. Values of the stem cell percentage and total cell number, as calculated from the model, and experimentally observed in developing colonies, are in satisfactory agreement, provided the chain of differentiating erythroblasts is expanded. © 1969.

引用

页码：249 / &

共 18 条

[1]

BELLMAN E, 1948, P NATN ACAD SCI USA, V34, P601

[2] HEMOPOIETIC SPLEEN COLONY STUDIES .2. ERYTHROPOIESIS [J].