SMALLEST GENOME RNA SEGMENT OF INFLUENZA-VIRUS CONTAINS 2 GENES THAT MAY OVERLAP

被引：113

作者：

INGLIS, SC ^{[1
]}

BARRETT, T ^{[1
]}

BROWN, CM ^{[1
]}

ALMOND, JW ^{[1
]}

机构：

[1] GESELL MBH,SANDOZ FORSCH INST,A-1235 WIEN,AUSTRIA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.3790

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genome of influenza virus consists of eight segments of single-stranded RNA, each of which encodes a different polypeptide. In addition to the eight recognized gene products, the virus specifies a distinct smaller nonstructural polypeptide (NS2), which is translated from a separate species of virus-specific mRNA. The location on the virus genome of the gene encoding this polypeptide was investigated by hybridization of the NS2 mRNA with isolated subgenomic RNA species, and by correlation of the inheritance of a strain-specific NS2 with inheritance of particular genome RNA segments during recombination between two different virus strains. The genetic information for NS2 was found to reside in the smallest genome RNA segment of the virion, which also encodes the NS1 polypeptide. Considering the sizes of the molecules involved, it is likely that the coding sequences for the two polypeptides overlap.

引用

页码：3790 / 3794

页数：5

共 35 条

[1] SINGLE GENE DETERMINES HOST RANGE OF INFLUENZA-VIRUS [J].