MICROEMULSIONS AS TOPICAL DRUG DELIVERY VEHICLES - INVITRO TRANSDERMAL STUDIES OF A MODEL HYDROPHILIC DRUG

被引：107

作者：

OSBORNE, DW ^{[1
]}

WARD, AJI ^{[1
]}

ONEILL, KJ ^{[1
]}

机构：

[1] CLARKSON UNIV,DEPT CHEM,POTSDAM,NY 13676

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03511.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microemulsions with a 58:42 weight ratio of dioctyl sodium sulphosuccinate: octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across human cadaver skin. A flow-through multisample skin diffusion cell showed that both the 35 and 68% water microemulsions caused enhanced (approximately 30-fold) transport of glucose. No transport was discernible for the 15% water microemulsion. Differences in percutaneous glucose transport were shown to parallel differences in the diffusion of water within the microemulsion vehicles before application to the skin.

引用

页码：451 / 454

页数：4

共 8 条

[1] ETHER WATER PARTITIONING AND PERMEABILITY THROUGH NUDE-MOUSE SKIN INVITRO .1. UREA, THIOUREA, GLYCEROL AND GLUCOSE [J].