PTERIN CHEMISTRY .71. SEPARATION OF THE DIASTEREOMERS "(6R)-5,6,7,8-TETRAHYDRO-L-NEOPTERIN AND "(6S)-5,6,7,8-TETRAHYDRO-L-NEOPTERIN

Separation of the Diastereomers (6R) and (6S)‐5,6,7,8‐Tetrahydro‐L‐neopterin The mixture of the diastereomers of the pentaacetylderivative IV of (6RS)‐5,6,7,8‐tetrahydro‐L‐neopterins could be separated by fractional crystallisation in methanol into the diastereomers IV A and IV B. Hydrolysis with hydrochloric acid gives the pure, diastereomeric, (6R)‐ and (6S)‐5,6,7,8‐tetrahydro‐L‐neopterins. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim