ETHICAL DILEMMAS IN MALARIA DRUG AND VACCINE TRIALS - A BIOETHICAL PERSPECTIVE

被引:19
作者
BARRY, M [1 ]
MOLYNEUX, M [1 ]
机构
[1] UNIV LIVERPOOL,LIVERPOOL SCH TROP MED,LIVERPOOL L3 5QA,ENGLAND
关键词
MALARIA VACCINE TRIALS; ETHICS; DEVELOPING COUNTRIES; INFORMED CONSENT; MALARIA DRUG TRIALS;
D O I
10.1136/jme.18.4.189
中图分类号
B82 [伦理学(道德学)];
学科分类号
摘要
Malaria is a disease of developing countries whose local health services do not have the time, resources or personnel to mount studies of drugs or vaccines without the collaboration and technology of western investigators. This investigative collaboration requires a unique bridging of cultural differences with respect to human investigation. The following debate, sponsored by The Institute of Medicine and The American Society of Tropical Medicine and Hygiene, raises questions concerning the conduct of trans-cultural clinical malaria research. Specific questions are raised about the difficulties of informed consent in different cultural settings and whether there is any role for community involvement. Discussants debate whether drug and vaccine trials not approved in an industrialised country are ever defensible if performed in a third-world setting. Potential conflicting priorities between investigators are discussed and ideas regarding conflict resolution are offered.
引用
收藏
页码:189 / 192
页数:4
相关论文
共 14 条
[1]   TABOOS AND CLINICAL RESEARCH IN WEST-AFRICA [J].
AJAYI, OO .
JOURNAL OF MEDICAL ETHICS, 1980, 6 (02) :61-63
[3]  
BEAUCHAMP TL, 1983, PRINCIPLES BIOMEDICA, P339
[4]   THE LUGANO STATEMENTS ON CONTROLLED CLINICAL-TRIALS [J].
BLUM, AL ;
CHALMERS, TC ;
DEUTSCH, E ;
KOCHWESER, J ;
ROSEN, A ;
TYGSTRUP, N ;
ZENTGRAF, R .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1987, 15 (01) :2-22
[5]  
*CIOMS, 1991, LAW MED HLTH CAR, V19, P3
[6]  
DECRAEMER W, 1983, MILBANK FUND Q, V61, P19
[7]  
Hall Andrew J, 1989, IRB, V11, P8, DOI 10.2307/3564470
[8]  
HENDERSON DA, 1973, B WORLD HEALTH ORGAN, V84, P183
[9]   HIGH-DOSE DEXAMETHASONE IN QUININE-TREATED PATIENTS WITH CEREBRAL MALARIA - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
HOFFMAN, SL ;
RUSTAMA, D ;
PUNJABI, NH ;
SURAMPAET, B ;
SANJAYA, B ;
DIMPUDUS, AJ ;
MCKEE, KT ;
PALEOLOGO, FP ;
CAMPBELL, JR ;
MARWOTO, H ;
LAUGHLIN, L .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (02) :325-331
[10]  
MOLYNEUX ME, 1989, Q J MED, V71, P265