48-HOUR RAPID-CYCLING - RESULTS OF PSYCHOPATHOMETRIC, POLYSOMNOGRAPHIC, PET IMAGING AND NEUROENDOCRINE LONGITUDINAL INVESTIGATIONS IN A SINGLE-CASE

被引：19

作者：

GANN, H ^{[1
]}

RIEMANN, D ^{[1
]}

HOHAGEN, F ^{[1
]}

STRAUSS, LG ^{[1
]}

DRESSING, H ^{[1
]}

MULLER, WE ^{[1
]}

BERGER, M ^{[1
]}

机构：

[1] CENT INST MENTAL HLTH,J5,POB 122120,W-6800 MANNHEIM,GERMANY

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1993年 / 28卷 / 02期

关键词：

RAPID CYCLING AFFECTIVE DISORDER; SLEEP EEG; HGH; CORTISOL; TSH; FT(4);

D O I：

10.1016/0165-0327(93)90042-I

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (positron emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a positive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.

引用

页码：133 / 140

页数：8

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