ACTIVATION OF SPECIFIC CORTICAL REGIONS BY APOMORPHINE - AN [O-15]H2O PET STUDY IN HUMANS

被引：32

作者：

KAPUR, S

MEYER, J

WILSON, AA

HOULE, S

BROWN, GM

机构：

[1] The Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, Toronto, Ont. M5T 1R8

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

关键词：

APOMORPHINE; DOPAMINE; CORTEX; PET; HUMAN;

D O I：

10.1016/0304-3940(94)90861-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to investigate the functional effects of apomorphine, a non-selective dopamine agonist, on regional neuronal activity using regional cerebral blood flow, measured using [O-15]H2O and positron emission tomography (PET), as an index. Eight normal volunteers were scanned twice before and twice after receiving 10 mu g/kg subcutaneous apomorphine. Apomorphine produced the expected side-effects and endocrine response. Analysis of the PET scans revealed that apomorphine increased regional cerebral blood flow (rCBF), presumably reflecting a change in neuronal activity, in the anterior cingulate, ventral motor cortex and the dorsolateral prefrontal cortex along with a decrease in rCBF in the retrosplenial cingulate region. These regions form a functional network of brain regions modulated by the dopaminergic system.

引用

页码：21 / 24

页数：4

共 23 条

[1] FUNCTIONAL ARCHITECTURE OF BASAL GANGLIA CIRCUITS - NEURAL SUBSTRATES OF PARALLEL PROCESSING [J].