INFLUENCE OF BETA-CYCLODEXTRIN CONCENTRATION AND POLYACRYLIC-ACID MOLECULAR-WEIGHT ON SWELLING AND RELEASE CHARACTERISTICS OF METOCLOPRAMIDE-CONTAINING HYDROGELS

被引：8

作者：

GARCIAGONZALEZ, N ^{[1
]}

KELLAWAY, IW ^{[1
]}

BLANCOFUENTE, H ^{[1
]}

ANGUIANOIGEA, S ^{[1
]}

DELGADOCHARRO, B ^{[1
]}

OTEROESPINAR, FJ ^{[1
]}

BLANCOMENDEZ, J ^{[1
]}

机构：

[1] UWCC,WELSH SCH PHARM,DIV PHARMACEUT,CARDIFF,WALES

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

BIOADHESIVE HYDROGEL; METOCLOPRAMIDE; SWELLING; DISSOLUTION; BETA-CYCLODEXTRIN; CARBOPOL;

D O I：

10.1016/0378-5173(93)90071-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (beta-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased beta-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency.

引用

页码：25 / 31

页数：7

共 21 条

[1]

GARCIAGONZALEZ N, 1992, STP PHARMA SCI, V2, P494

[2] CYCLODEXTRIN-CONTAINING POLYMERS .2. COOPERATIVE EFFECTS IN CATALYSIS AND BINDING [J].