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KERATIN DISEASES

被引：45
作者：
LANE, EB
机构：
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 03期
关键词：
D O I：
10.1016/0959-437X(94)90030-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The recent discovery that epidermal fragility syndromes can be caused by mutations in the genes for keratin intermediate filaments has been a turning point for research into these structural proteins. Clustering of pathogenic mutations implies differential structural sensitivity along the keratin molecule, and implications for filament function require a new look at culture assay systems, plus a reassessment of structural defects in epithelia and other tissues.
引用
收藏
页码：412 / 418
页数：7
相关论文
共 48 条
  • [1] AUTOSOMAL RECESSIVE EPIDERMOLYSIS-BULLOSA SIMPLEX - A CASE-REPORT
    ABANMI, A
    JOSHI, RK
    ATUKORALA, DN
    PEDERSEN, NB
    KHAMIS, OA
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1994, 130 (01) : 115 - 117
  • [2] THE EXPRESSION OF MUTANT EPIDERMAL KERATIN CDNAS TRANSFECTED IN SIMPLE EPITHELIAL AND SQUAMOUS-CELL CARCINOMA LINES
    ALBERS, K
    FUCHS, E
    [J]. JOURNAL OF CELL BIOLOGY, 1987, 105 (02) : 791 - 806
  • [3] EXPRESSION OF MUTANT KERATIN CDNAS IN EPITHELIAL-CELLS REVEALS POSSIBLE MECHANISMS FOR INITIATION AND ASSEMBLY OF INTERMEDIATE FILAMENTS
    ALBERS, K
    FUCHS, E
    [J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (04) : 1477 - 1493
  • [4] CONCERTED GENE DUPLICATIONS IN THE 2 KERATIN GENE FAMILIES
    BLUMENBERG, M
    [J]. JOURNAL OF MOLECULAR EVOLUTION, 1988, 27 (03) : 203 - 211
  • [5] BONIFAS JM, 1991, J INVEST DERMATOL, V96, P550
  • [6] EPIDERMOLYSIS-BULLOSA SIMPLEX - EVIDENCE IN 2 FAMILIES FOR KERATIN GENE ABNORMALITIES
    BONIFAS, JM
    ROTHMAN, AL
    EPSTEIN, EH
    [J]. SCIENCE, 1991, 254 (5035) : 1202 - 1205
  • [7] THE GENETIC-BASIS OF WEBER-COCKAYNE EPIDERMOLYSIS-BULLOSA SIMPLEX
    CHAN, YM
    YU, QC
    FINE, JD
    FUCHS, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) : 7414 - 7418
  • [8] A NOVEL 3-NUCLEOTIDE DELETION IN THE HELIX 2B REGION OF KERATIN-14 IN EPIDERMOLYSIS-BULLOSA SIMPLEX - DELTA-E375
    CHEN, MA
    BONIFAS, JM
    MATSUMURA, K
    BLUMENFELD, A
    EPSTEIN, EH
    [J]. HUMAN MOLECULAR GENETICS, 1993, 2 (11) : 1971 - 1972
  • [9] THE GENETIC-BASIS OF EPIDERMOLYTIC HYPERKERATOSIS - A DISORDER OF DIFFERENTIATION-SPECIFIC EPIDERMAL KERATIN GENES
    CHENG, J
    SYDER, AJ
    YU, QC
    LETAI, A
    PALLER, AS
    FUCHS, E
    [J]. CELL, 1992, 70 (05) : 811 - 819
  • [10] CHIPEV CC, 1994, AM J HUM GENET, V54, P179
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