STUDIES IN RELATION TO BIOSYNTHESIS .41. CANESCIN

被引：7

作者：

BIRCH, AJ

GAGER, F

MO, L

PELTER, A

WRIGHT, JJ

机构：

[1] Chemistry Department, University of Manchester

[2] Research School of Chemistry, Australian National University, Canberra, ACT

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1969年 / 22卷 / 11期

关键词：

D O I：

10.1071/CH9692429

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biosynthesis of canescin (I) has been investigated. The isocoumarin portion is derived from a polyketide chain. One carbon atom of the γ-lactone ring and the carbon atom of the methoxyl group originate from methionine whilst the other three carbon atoms of the γ-lactone have a symmetrical C4-acid of the citric acid cycle as their precursor. This metabolite is most unusual in that an oxygenated methionine-derived carbon atom provides the growing point of a new carbon chain. A possible mechanism for the attachment of the lactone is suggested. © 1969, CSIRO. All rights reserved.

引用

页码：2429 / &

共 14 条

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[2] STRUCTURES OF CANESCIN-A AND -B
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NES, WR
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