FRAMESHIFT MUTATIONS IN BACTERIA PRODUCED IN DARK BY SEVERAL FUROCOUMARINS - ABSENCE OF ACTIVITY OF 4,5',8-TRIMETHYLPSORALEN

被引：22

作者：

ASHWOODSMITH, MJ ^{[1
]}

机构：

[1] UNIV DIJON,F-21000 DIJON,FRANCE

来源：

MUTATION RESEARCH | 1978年 / 58卷 / 01期

关键词：

D O I：

10.1016/0165-1218(78)90091-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

4 furocoumarins, namely psoralen (P), 8-methoxypsoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) and angelicin (A) were tested for dark mutagenesis in E. coli lac-. Three compounds; P, 8-MOP and A were shown to be weak frameshift mutagens. TMP, surprisingly in view of its very active photosensitizing action, was found to be non-mutagenic. These results are discussed in relation to the photosensitizing action of the furocoumarins. © 1978.

引用

页码：23 / 27

页数：5

共 13 条

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