EFFECT OF LOCOMOTOR-ACTIVITY ON CEREBELLAR LEVELS ON CGMP

被引：28

作者：

MEYERHOFF, JL

LENOX, RH

KANT, GJ

SESSIONS, GR

MOUGEY, EH

PENNINGTON, LL

机构：

[1] Department of Medical Neurosciences, Division of Neuropsychiatry Walter Reed Army Institute of Research Washington

来源：

LIFE SCIENCES | 1979年 / 24卷 / 12期

关键词：

D O I：

10.1016/0024-3205(79)90047-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of locomotor activity on brain regional levels of cyclic guanosine 3′, 5′-monophosphate (cGMP) and cyclic adenosine 3′, 5′-monophosphate (cAMP) was examined in rats trained to run in an activity wheel. Following 5 minutes of running, there was a two-fold elevation over control levels of cerebellar cGMP. Significant elevations were seen in eight other regions. No changes were observed in cAMP. Plasma levels of hormones indicative of stress were not significantly different between groups. We suggest that locomotor activity may contribute to elevations in cGMP in cerebellum and other brain regions in rats exposed to a variety of conditions. © 1979.

引用

页码：1125 / 1130

页数：6

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