GROUP-SPECIFIC COMPONENT (GC) SUBTYPES OF GC1 BY ISOELECTRIC-FOCUSING IN UNITED-STATES BLACKS AND WHITES

Isoelectric focusing was applied to the Gc polymorphism. In agreement with Constans et al., the authors found two common 'subtypes' of Gc1 that could not be identified by conventional electrophoretic procedures. They are labeled Gc1F and Gc1S. Gc1F has a slightly lower isoelectric point than Gc1S. In groups of US blacks the allele frequencies were for Gc1F; 0.732 and for Gc1S; 0.147. In whites these figures were 0.149 and 0.572. The authors also found GcAb in blacks with a frequency of 0.015. The concentrations in serum of Gc protein as measured by radial immunodiffusion did not differ according to phenotype.