INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS

被引：107

作者：

CLEMMONS, DR

机构：

[1] Department of Medicine, University of North Carolina School of Medicine, Chapel Hill

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1990年 / 1卷 / 08期

关键词：

D O I：

10.1016/1043-2760(90)90102-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulinlike growth factor binding proteins (IGFBPs), which are often present in extracellular fluids, have the potential to markedly alter IGF-receptor interaction. There are at least four specific forms of IGFBPs in blood. These forms are also secreted by a number of cell types. Their rates of secretion and clearance appear to be regulated, mostly by hormones. Their major role seems to be to alter the interaction of IGFs with their cell surface receptors. Other functions such as transport out of the vasculature and modulating target cell actions also appear to be important. © 1990.

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页码：412 / 417

页数：6

相关论文

共 45 条

[1] RELEASE OF INSULIN-LIKE GROWTH-FACTORS AND BINDING-PROTEIN ACTIVITY INTO SERUM-FREE MEDIUM OF CULTURED HUMAN-FIBROBLASTS [J].

ADAMS, SO ;

KAPADIA, M ;

MILLS, B ;

DAUGHADAY, WH .

ENDOCRINOLOGY, 1984, 115 (02) :520-526

[2] PRODUCTION OF IGF-BINDING PROTEINS BY VASCULAR ENDOTHELIAL-CELLS [J].

BAR, RS ;

HARRISON, LC ;

BAXTER, RC ;

BOES, M ;

DAKE, BL ;

BOOTH, B ;

COX, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) :734-739

[3] CHARACTERIZATION OF THE ACID-LABILE SUBUNIT OF THE GROWTH HORMONE-DEPENDENT INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN COMPLEX [J].

BAXTER, RC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (02) :265-272

[4] RADIOIMMUNOASSAY OF GROWTH-HORMONE DEPENDENT INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN IN HUMAN-PLASMA [J].

BAXTER, RC ;

MARTIN, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (06) :1504-1512

[5] DIURNAL RHYTHM OF GROWTH HORMONE-INDEPENDENT BINDING-PROTEIN FOR INSULIN-LIKE GROWTH-FACTORS IN HUMAN-PLASMA [J].

BAXTER, RC ;

COWELL, CT .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (03) :432-440

[6]

BAYNE ML, 1988, J BIOL CHEM, V263, P6233

[7] INSULIN-LIKE GROWTH FACTOR-I (IGF-I)-BINDING PROTEIN COMPLEX IS A BETTER MITOGEN THAN FREE IGF-I [J].

BLUM, WF ;

JENNE, EW ;

REPPIN, F ;

KIETZMANN, K ;

RANKE, MB ;

BIERICH, JR .

ENDOCRINOLOGY, 1989, 125 (02) :766-772

[8] CLONING, CHARACTERIZATION, AND EXPRESSION OF A HUMAN INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN [J].

BREWER, MT ;

STETLER, GL ;

SQUIRES, CH ;

THOMPSON, RC ;

BUSBY, WH ;

CLEMMONS, DR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (03) :1289-1297

[9] ORGANIZATION OF THE GENE ENCODING THE INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN IBP-1 [J].

BRINKMAN, A ;

GROFFEN, CAH ;

KORTLEVE, DJ ;

DROP, SLS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (03) :898-907

[10]

BROWN AL, 1989, J BIOL CHEM, V264, P5148

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