CHARACTERIZATION OF POLYETHYLENE GLYCOLS USING SOLUTION CALORIMETRY

被引：28

作者：

CRAIG, DQM

NEWTON, JM

机构：

[1] The School of Pharmacy, University of London, London, WC1N 1AX

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 74卷 / 01期

关键词：

POLYETHYLENE GLYCOL; SOLUTION CALORIMETRY; MOLECULAR WEIGHT; THERMODYNAMIC ANALYSIS; THERMAL TREATMENT; SOLID DISPERSION;

D O I：

10.1016/0378-5173(91)90406-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The heats of solution of a range of polyethylene glycols (PEGs) have been measured using samples prepared under various heating and cooling protocols. The values obtained were shown to be highly sensitive to both PEG molecular weight and to the thermal history of the sample. A model has been proposed in order to interpret the results in terms of the energetics of the different stages of the dissolution process.

引用

页码：43 / 48

页数：6

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