EXPRESSION OF THE SIGNAL TRANSDUCING REGIONS OF CD4-LIKE AND LCK GENES IN MURINE EGG

被引：20

作者：

MORI, T ^{[1
]}

GOU, MW ^{[1
]}

YOSHIDA, H ^{[1
]}

SAITO, S ^{[1
]}

MORI, E ^{[1
]}

机构：

[1] KIRIN PHARMACEUT LAB, MAEBASHI, GUNMA 307, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91764-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously demonstrated that the MHC class II molecule on murine sperm and CD4-like molecule on the egg vitelline membrane are involved in fertilization. In this study, the RNA transcripts in murine eggs corresponding to parts of the CD4 gene and lck gene in thymocytes were demonstrated by means of the reverse transcriptase (RT)/polymerase chain reaction (PCR) followed by the sequencing of the PCR products. The deduced sequences potentially encode the amino acid sequence of the transmembrane to the cytoplasmic domain of CD4 and that of the N-terminal domain of p56lck respectively. These findings indicate that a signal transducing complex similar to that in immune T cells is expressed at the transcriptional level in murine eggs. © 1992.

引用

页码：527 / 533

页数：7