COMMON MECHANISMS FOR THE CONTROL OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION

被引：74

作者：

KRUMM, A

MEULIA, T

GROUDINE, M

机构：

[1] FRED HUTCHINSON CANC RES CTR, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA

[2] UNIV WASHINGTON, SCH MED, DEPT RADIAT ONCOL, SEATTLE, WA 98195 USA

来源：

BIOESSAYS | 1993年 / 15卷 / 10期

关键词：

D O I：

10.1002/bies.950151005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of transcriptional elongation is emerging as an important control mechanism for eukaryotic gene expression. In this essay, we review the basis of the current view of the regulation of elongation in the human c-myc gene and discuss similarities in elongation control among the c-myc, Drosophila hsp70 and the HIV-1 genes. Based upon these similarities, we propose a model for control of expression of these genes at the elongation phase of transcription. This model suggests that distinct promoter elements direct the assembly of RNA polymerase II transcription complexes which differ in their elongation efficiency.

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收藏

页码：659 / 665

页数：7

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