PROTECTIVE EFFECTS OF VITAMIN-C AND VITAMIN-E AGAINST GAMMA-RAY-INDUCED CHROMOSOMAL DAMAGE IN MOUSE

被引：108

作者：

SARMA, L ^{[1
]}

KESAVAN, PC ^{[1
]}

机构：

[1] JAWAHARLAL NEHRU UNIV, SCH LIFE SCI, NEW DELHI 110067, INDIA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1993年 / 63卷 / 06期

关键词：

D O I：

10.1080/09553009314552161

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of vitamins C and E on bone marrow chromosomes of the mouse exposed to 1 Gy of whole-body gamma-irradiation were studied. These vitamins, dissolved in water/peanut oil, were administered orally as acute doses, either 2 h before, immediately after, or 2 h after irradiation. Both vitamins significantly reduced the frequencies of micronuclei and chromosomal aberrations in bone marrow cells; radioprotection by vitamin E was, however, appreciably greater than that afforded by vitamin C. Administration of the vitamins to mice immediately after irradiation was as effective as that 2 h before irradiation. A sequential treatment consisting of both these vitamins did not result in additional radioprotection over that afforded by vitamin E alone. The probable mechanisms of radioprotection are discussed.

引用

页码：759 / 764

页数：6

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