POTENTIATION OF PURINERGIC NEUROTRANSMISSION IN GUINEA-PIG URINARY-BLADDER BY HISTAMINE

被引:19
作者
PATRA, PB [1 ]
WESTFALL, DP [1 ]
机构
[1] UNIV NEVADA,SCH MED,DEPT PHARMACOL,RENO,NV 89557
关键词
GUINEA PIGS; HISTAMINE; BLADDER; NEUROREGULATORS; CYSTITIS;
D O I
10.1016/S0022-5347(17)35088-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Patients suffering from the inflammatory condition of interstitial cystitis frequently exhibit an increased number of mast cells in the bladder. To determine whether mast cell mediators have the potential to influence the neurogenic contraction of the bladder smooth muscle and thereby possibly contribute to the symptoms of interstitial cystitis, we examined the effects of histamine, a major inflammatory mediator of mast cell origin, on nerve- and agonist-induced contractions of in vitro strips of guinea pig urinary bladder. Histamine (10 mu M.) potentiated by more than 50% the nerve-induced contraction of bladder strips evoked by field stimulation with 0.5 msec. pulses at 4 Hz. Because the neurogenic contraction of the bladder is mediated by at least two neurotransmitters, acetylcholine (ACh) and ATP, we examined the effects of histamine on each of these transmitters. Histamine potentiated responses to the purinergic component of the neurogenic response (that part of the neurogenic response that remains after treatment with atropine) and potentiated responses to exogenously applied ATP. Histamine did not potentiate the response to the cholinergic component of the neurogenic response (that part of the neurogenic response that remains after desensitization of purinoceptors with alpha, beta-methylene ATP) nor responses to carbachol, a cholinergic agonist. These results indicate that histamine potentiates the neurogenic response of the bladder by influencing the purinergic component, apparently at postjunctional sites.
引用
收藏
页码:787 / 790
页数:4
相关论文
共 15 条
[1]   NON-CHOLINERGIC TRANSMISSION BY POST-GANGLIONIC MOTOR NEURONES IN MAMMALIAN BLADDER [J].
AMBACHE, N ;
ZAR, MA .
JOURNAL OF PHYSIOLOGY-LONDON, 1970, 210 (03) :761-+
[2]  
ANDERSON GF, 1982, J PHARMACOL EXP THER, V220, P347
[3]   DIRECT EVIDENCE FOR ATP RELEASE FROM NON-ADRENERGIC, NON-CHOLINERGIC (PURINERGIC) NERVES IN GUINEA-PIG TAENIA-COLI AND BLADDER [J].
BURNSTOCK, G ;
COCKS, T ;
KASAKOV, L ;
WONG, HK .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 49 (02) :145-149
[4]   ROLE OF PROSTAGLANDINS IN EXCITATORY INNERVATION OF RAT URINARY-BLADDER [J].
CHOO, LK ;
MITCHELSON, F .
PROSTAGLANDINS, 1977, 13 (05) :917-926
[5]   NEUROTRANSMISSION IN THE URINARY-BLADDER OF RABBITS AND GUINEA-PIGS [J].
CREED, KE ;
ITO, Y ;
KATSUYAMA, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (02) :C271-C277
[6]   EVIDENCE FOR ADENOSINE-TRIPHOSPHATE AS AN EXCITATORY TRANSMITTER IN GUINEA-PIG, RABBIT AND PIG URINARY-BLADDER [J].
FUJII, K .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :39-52
[7]   DIAGNOSIS OF INTERSTITIAL CYSTITIS [J].
HANNO, P ;
LEVIN, RM ;
MONSON, FC ;
TEUSCHER, C ;
ZHOU, ZZ ;
RUGGIERI, M ;
WHITMORE, K ;
WEIN, AJ .
JOURNAL OF UROLOGY, 1990, 143 (02) :278-281
[8]  
KASAKOV L, 1983, European Journal of Pharmacology, V86, P291
[9]   HISTAMINE CONTENT AND MAST-CELL COUNT OF DETRUSOR MUSCLE IN PATIENTS WITH INTERSTITIAL CYSTITIS AND OTHER TYPES OF CHRONIC CYSTITIS [J].
KASTRUP, J ;
HALD, T ;
LARSEN, S ;
NIELSEN, VG .
BRITISH JOURNAL OF UROLOGY, 1983, 55 (05) :495-500
[10]   THE NATURAL-HISTORY OF INTERSTITIAL CYSTITIS - A SURVEY OF 374 PATIENTS [J].
KOZIOL, JA ;
CLARK, DC ;
GITTES, RF ;
TAN, EM .
JOURNAL OF UROLOGY, 1993, 149 (03) :465-469