PRECONDITIONING WITH DOBUTAMINE IN THE ISOLATED RAT-HEART

被引：19

作者：

ASIMAKIS, GK

CONTI, VR

机构：

[1] Division of Cardiothoracic Surgery, Department of Surgery The University, Texas Medical Branch Galveston, TX

来源：

LIFE SCIENCES | 1995年 / 57卷 / 02期

关键词：

DOBUTAMINE; PRECONDITIONING; ISCHEMIA; HEART;

D O I：

10.1016/0024-3205(95)00258-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min ''washout'' period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate x developed pressure, end diastolic pressure, and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10(-6)M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve beta-adrenergic stimulation.

引用

页码：177 / 187

页数：11

共 31 条

[1]

Murry, Jennings, Reimer, Circulation, 24, pp. 1124-1136, (1986)

[2]

Schott, Rohmann, Braun, Schaper, Circ. Res., 66, pp. 1133-1142, (1990)

[3]

Liu, Thornton, Vanwinkle, Stanley, Olsson, Downey, Circulation, 84, pp. 350-356, (1991)

[4]

Liu, Downey, Am.J. Physiol., 263, pp. H1107-H1112, (1992)

[5]

Shiki, Hearse, Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias., Am J Physiol, 253, pp. H1470-H1476, (1987)

[6]

Hagar, Hale, Kloner, Circ. Res., 68, pp. 61-68, (1991)

[7]

Asimakis, Inners-Mcbride, Medellin, Conti, Am.J. Physiol., 263, pp. H887-H894, (1992)

[8]

Cave, Collins, Downey, Hearse, Cardiovasc Res., 27, pp. 663-668, (1993)

[9]

Steenbergen, Perlman, London, Murphy, Circ. Res., 72, pp. 112-125, (1993)

[10]

Banerjee, Locke-Winter, Rogers, Mitchell, Brew, Cairns, Bensard, Harken, Circ. Res., 73, pp. 656-670, (1993)

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