16,19-CIS-MURISOLIN AND MURISOLIN-A, 2 NOVEL BIOACTIVE MONO-TETRAHYDROFURAN ANNONACEOUS ACETOGENINS FROM ASIMINA-TRILOBA SEEDS

被引：44

作者：

WOO, MH

ZENG, L

YE, Q

GU, ZM

ZHAO, GX

MCLAUGHLIN, JL

机构：

[1] PURDUE UNIV, SCH PHARM & PHARMACAL SCI, DEPT MED CHEM & PHARMACOGNOSY, W LAFAYETTE, IN 47907 USA

[2] TAEGU HYOSUNG CATHOLIC UNIV, COLL PHARM, DEPT PHARM, KYONGSAN 713702, SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/0960-894X(95)00182-S

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two novel bioactive mono-tetrahydrofuran (THF) gamma-lactone acetogenins, 16,19-cis-murisolin (1) and murisolin A (2), were isolated from the seeds of Asimina triloba (Annonaceae) by directing the fractionation with brine shrimp lethality. 1 has a 16,19-cis mono-THF ring with two flanking hydroxyl groups and represents a new type among the natural Annonaceous acetogenins. Murisolin (3), which is new in this species, was also obtained. 1-3 showed potent and selective cytotoxicities among six human tumor cell lines.

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页码：1135 / 1140

页数：6

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