HALOMETHANE HEPATOTOXICITY - INDUCTION OF LIPID-PEROXIDATION AND INACTIVATION OF CYTOCHROME-P-450 IN RAT-LIVER MICROSOMES UNDER LOW OXYGEN PARTIAL PRESSURES

被引：13

作者：

DEGROOT, H

NOLL, T

机构：

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1989年 / 97卷 / 03期

关键词：

D O I：

10.1016/0041-008X(89)90258-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：530 / 537

页数：8

共 34 条

[1]

AHMED AE, 1977, DRUG METAB DISPOS, V5, P198

[2]

BRATTIN W J, 1985, Journal of Free Radicals in Biology and Medicine, V1, P27, DOI 10.1016/0748-5514(85)90026-1

[3] BIOCHEMICAL-STUDIES ON THE METABOLIC-ACTIVATION OF HALOGENATED ALKANES [J].

CHEESEMAN, KH ;

ALBANO, EF ;

TOMASI, A ;

SLATER, TF .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 64 :85-101

[4] SELF-CATALYZED, O2-INDEPENDENT INACTIVATION OF NADPH-REDUCED OR DITHIONITE-REDUCED MICROSOMAL CYTOCHROME-P-450 BY CARBON-TETRACHLORIDE [J].

DEGROOT, H ;

HAAS, W .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (16) :2343-2347

[5]

DEGROOT H, 1983, HEPATOLOGY, V3, P601

[6] THE CRUCIAL ROLE OF HYPOXIA IN HALOTHANE-INDUCED LIPID-PEROXIDATION [J].

DEGROOT, H ;

NOLL, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 119 (01) :139-143

[7] THE CRUCIAL ROLE OF LOW STEADY-STATE OXYGEN PARTIAL PRESSURES IN HALOALKANE FREE-RADICAL-MEDIATED LIPID-PEROXIDATION - POSSIBLE IMPLICATIONS IN HALOALKANE LIVER-INJURY [J].

DEGROOT, H ;

NOLL, T .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :15-19

[8] THE ROLE OF PHYSIOLOGICAL OXYGEN PARTIAL PRESSURES IN LIPID-PEROXIDATION - THEORETICAL CONSIDERATIONS AND EXPERIMENTAL-EVIDENCE [J].

DEGROOT, H ;

NOLL, T .

CHEMISTRY AND PHYSICS OF LIPIDS, 1987, 44 (2-4) :209-226

[9]

DEGROOT H, 1980, FEBS LETT, V115, P253

[10] SUICIDAL INACTIVATION OF MICROSOMAL CYTOCHROME-P-450 BY HALOTHANE UNDER HYPOXIC CONDITIONS [J].

DEGROOT, H ;

HARNISCH, U ;

NOLL, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 107 (03) :885-891

← 1 2 3 4 →