IMPROVED SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES

被引：63

作者：

STENGELE, KP ^{[1
]}

PFLEIDERER, W ^{[1
]}

机构：

[1] UNIV CONSTANCE,FAK CHEM,POSTFACH 5560,W-7750 CONSTANCE,GERMANY

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 18期

关键词：

D O I：

10.1016/0040-4039(90)80122-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design of a new polymer support in combination with the well experienced β-eliminating protecting groups offers an improved approach for automated oligonucleotide synthesis. The advantages are notorious by the possibility of preparing fully deblocked still support-bound oligomers, which result on final liberation in high yield, easy isolation and high purity. This approach also reveals some options, which have so far not been realized in the field of solid phase synthesis of nucleic acid fragments. © 1990.

引用

页码：2549 / 2552

页数：4

共 10 条

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