COMPLETE SEQUENCE OF THE GAMMA-CHAIN FROM THE FETAL HEMOGLOBIN OF THE BABOON, PAPIO-CYNOCEPHALUS

The amino acid sequence of the hemoglobin γ chain from a baboon, Papio cynocephalus, was determined by automated sequencing of the intact chain and six fragments generated by specific cleavage reactions. the existence of structural heterogeneity at position 75, where both valyl and isoleucyl residues were found, is suggestive of the presence of nonallelic Vγ and Iγchain genes in this species, and further emphasizes the extent to which the genetic basis of hemoglobin production among many higher primates is similar. Comparison of the sequences of those γ chains from Homo sapiens, Pan troglodytes, Macaca nemestrina and P. cynocephalus that have been well characterized attests to the conservative nature of γchain evolution among the Anthropoidea, the differences in sequence between any two of these chains ranging from none (between the Aγ and Gγ chains of P. troglodytes and H. sapiens) to no more than five (between the Vγ chains of p. cynocephalus and the Aγ chains of H. sapiens). © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.