HYPOTENSIVE ACTION OF A COSCINIUM-FENESTRATUM STEM EXTRACT

被引：9

作者：

SINGH, GB ^{[1
]}

SINGH, S ^{[1
]}

BANI, S ^{[1
]}

MALHOTRA, S ^{[1
]}

机构：

[1] REG RES LAB,DIV NAT PROD,JAMMU 180001,INDIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1990年 / 30卷 / 02期

关键词：

D O I：

10.1016/0378-8741(90)90004-D

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A 50% ethanol extract of Coscinium fenestratum stem material (AECF) has been found to possess hypotensive action in anaesthetised dogs, rats and guinea pigs in a dose-related pattern. The fall in blood pressure was not modified by alpha and beta adrenergic blockers, cholinergic and histaminergic antagonists or by ganglion blocking agents. The effect was more pronounced in spinal-transected animals. AECF non-specifically inhibited the presser responses to epinephrine, norepinephrine, DMPP and depressor responses to acetylcholine and histamine. AECF failed to exhibit any hypotension when administered via cannula into the lateral cerebral ventricle. Given orally to mice, AECF did not exhibit grossly observable central nervous effects up to doses of 800 mg/kg. The oral LD50 was estimated to be 1200 mg/kg in mice. © 1990.

引用

页码：151 / 155

页数：5