2 LACTONE FORMATION REACTIONS FROM 1,3-DIOXIN-4-ONES HAVING HYDROXYALKYL GROUP AT THE 6-POSITION - DIFFERENCE IN RING-OPENING AND CLOSURE

被引：39

作者：

SATO, M

SAKAKI, J

SUGITA, Y

YASUDA, S

SAKODA, H

KANEKO, C

机构：

[1] Pharmaceutical Institute, Tohoku University, Sendai, 980, Aobayama

来源：

TETRAHEDRON | 1991年 / 47卷 / 30期

关键词：

D O I：

10.1016/S0040-4020(01)86522-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods (A: ring opening to acylketenes followed by intramolecular ketene trapping and B: methoxide-mediated ring opening followed by cyclization of the hydroxy esters thus formed) have become available for the synthesis of lactones and/or cyclic ethers from 1,3-dioxin-4-ones having 1-approximately 4-hydroxyalkyl group at the 6-position. Mechanism and scope of both methods have been clarified.

引用

收藏

页码：5689 / 5708

页数：20

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