GROWTH-HORMONE GENE-REGULATION BY TRANS-ACTING FACTORS

被引：10

作者：

ROUSSEAU, GG

机构：

[1] Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels

来源：

HORMONE RESEARCH | 1992年 / 37卷

关键词：

GROWTH HORMONE GENE EXPRESSION; GROWTH HORMONE FACTOR-I; SOMATOTROPHS; TRANSCRIPTION;

D O I：

10.1159/000182407

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The promoter sequence of the growth hormone (GH) gene binds the ubiquitous factors nuclear factor 1, activator protein-2, upstream stimulatory factor and Sp1. A pituitary-specific factor known as growth hormone factor 1 or Pit-1 also binds to the promoter sequence. This factor is responsible for somatotroph-specific expression of GH. It is also involved in the effect of GH-releasing hormone and in the ontogeny of the anterior pituitary.

引用

收藏

页码：88 / 92

页数：5

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